Influence of maternal immunity on the outcome of mutine coronavirus JHM infection in suckling mice
Identifieur interne : 001629 ( Main/Exploration ); précédent : 001628; suivant : 001630Influence of maternal immunity on the outcome of mutine coronavirus JHM infection in suckling mice
Auteurs : K. Pickel [Allemagne] ; M. A. Müller [Allemagne] ; V. Ter Meulen [Allemagne]Source :
- Medical Microbiology and Immunology [ 0300-8584 ] ; 1985-04-01.
English descriptors
- Teeft :
- Acta neuropathol, Adult mice, Antibody production, Antibody profile, Antibody titer, Antibody titers, Baby mice, Breast milk, Breast milk antibodies, Comparable antibody titers, Coronavirus, Crucial role, Days post partum, Days post transfer, Death days, Friend virus, High level, Immune, Immune mothers, Immune system, Immunization, Immunoglobulin, Infection, Intraperitoneal, Intraperitoneal infection, Jhmv, Jhmv infection, Lethal infection, Lethal outcome, Maternal immunity, Mouse, Mouse hepatitis virus, Murine coronavirus, Neutralizing, Neutralizing antibodies, Partum, Passive immunity, Plaque assay, Post infection, Post partum, Significant amount, Single immunization, Spleen cells, Suckling, Suckling mice, Tail vein, Titer, Total group, Total group occurrence, Various intervals, Various times.
Abstract
Abstract: Adult C3H mice are resistant to intraperitoneal infection with murine coronavirus JHM, whereas suckling offspring of non-immune females are susceptible. Resistance can be conferred on suckling C3H mice by postnatal transmission of maternal immunity, if transfer preceeds infection. Suckling mice succumb to infection even when they receive maternal antibodies within 1 day after infection. Prenatal transmission alone without subsequent postnatal transmission of maternal immunity is not sufficient to provide resistance. Persistence of virus without clinical consequences was observed when the supply of breast milk anti-JHMV antibodies was terminated 5 days before infection. Immune reactions restricted by histocompatibility antigens do not play a crucial role in bestowing resistance. As neutralizing anti-JHM serum antibody titers of adult mice only rise sharply 5 to 7 days after infection, these results indicate that infection of adults can be arrested by immunological means but that, in addition, the rate of virus dissemination must be limited by other non-immunological mechanisms.
Url:
DOI: 10.1007/BF02123666
Affiliations:
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Pickel</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Virology and Immunobiology, Versbacher Str. 7, D-8700, Würzburg</wicri:regionArea><wicri:noRegion>Würzburg</wicri:noRegion><wicri:noRegion>Würzburg</wicri:noRegion></affiliation></author><author><name sortKey="Muller, M A" sort="Muller, M A" uniqKey="Muller M" first="M. A." last="Müller">M. A. Müller</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Virology and Immunobiology, Versbacher Str. 7, D-8700, Würzburg</wicri:regionArea><wicri:noRegion>Würzburg</wicri:noRegion><wicri:noRegion>Würzburg</wicri:noRegion></affiliation></author><author><name sortKey="Ter Meulen, V" sort="Ter Meulen, V" uniqKey="Ter Meulen V" first="V." last="Ter Meulen">V. Ter Meulen</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Virology and Immunobiology, Versbacher Str. 7, D-8700, Würzburg</wicri:regionArea><wicri:noRegion>Würzburg</wicri:noRegion><wicri:noRegion>Würzburg</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Medical Microbiology and Immunology</title><title level="j" type="abbrev">Med Microbiol Immunol</title><idno type="ISSN">0300-8584</idno><idno type="eISSN">1432-1831</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1985-04-01">1985-04-01</date><biblScope unit="volume">174</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="15">15</biblScope><biblScope unit="page" to="24">24</biblScope></imprint><idno type="ISSN">0300-8584</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0300-8584</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acta neuropathol</term><term>Adult mice</term><term>Antibody production</term><term>Antibody profile</term><term>Antibody titer</term><term>Antibody titers</term><term>Baby mice</term><term>Breast milk</term><term>Breast milk antibodies</term><term>Comparable antibody titers</term><term>Coronavirus</term><term>Crucial role</term><term>Days post partum</term><term>Days post transfer</term><term>Death days</term><term>Friend virus</term><term>High level</term><term>Immune</term><term>Immune mothers</term><term>Immune system</term><term>Immunization</term><term>Immunoglobulin</term><term>Infection</term><term>Intraperitoneal</term><term>Intraperitoneal infection</term><term>Jhmv</term><term>Jhmv infection</term><term>Lethal infection</term><term>Lethal outcome</term><term>Maternal immunity</term><term>Mouse</term><term>Mouse hepatitis virus</term><term>Murine coronavirus</term><term>Neutralizing</term><term>Neutralizing antibodies</term><term>Partum</term><term>Passive immunity</term><term>Plaque assay</term><term>Post infection</term><term>Post partum</term><term>Significant amount</term><term>Single immunization</term><term>Spleen cells</term><term>Suckling</term><term>Suckling mice</term><term>Tail vein</term><term>Titer</term><term>Total group</term><term>Total group occurrence</term><term>Various intervals</term><term>Various times</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Adult C3H mice are resistant to intraperitoneal infection with murine coronavirus JHM, whereas suckling offspring of non-immune females are susceptible. Resistance can be conferred on suckling C3H mice by postnatal transmission of maternal immunity, if transfer preceeds infection. Suckling mice succumb to infection even when they receive maternal antibodies within 1 day after infection. Prenatal transmission alone without subsequent postnatal transmission of maternal immunity is not sufficient to provide resistance. Persistence of virus without clinical consequences was observed when the supply of breast milk anti-JHMV antibodies was terminated 5 days before infection. Immune reactions restricted by histocompatibility antigens do not play a crucial role in bestowing resistance. As neutralizing anti-JHM serum antibody titers of adult mice only rise sharply 5 to 7 days after infection, these results indicate that infection of adults can be arrested by immunological means but that, in addition, the rate of virus dissemination must be limited by other non-immunological mechanisms.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country></list><tree><country name="Allemagne"><noRegion><name sortKey="Pickel, K" sort="Pickel, K" uniqKey="Pickel K" first="K." last="Pickel">K. Pickel</name></noRegion><name sortKey="Muller, M A" sort="Muller, M A" uniqKey="Muller M" first="M. A." last="Müller">M. A. Müller</name><name sortKey="Ter Meulen, V" sort="Ter Meulen, V" uniqKey="Ter Meulen V" first="V." last="Ter Meulen">V. Ter Meulen</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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